We determine precisely those locally finite varieties of unary algebras of finite type which, when augmented by a ternary discriminator, generate a variety with a decidable theory.

In two recent studies we have examined the prose rhythms in the clausulae of late imperial Latin authors. We found two clausular systems to be prevalent, the cursus and the cursus mixtus. The cursus involves the use of accentual rhythms and consists of three basic cadences: planus, tardus, and velox. The cursus mixtus has been defined by modern scholars as a type of prose rhythm in which the clausula is structured along both accentual and metrical lines, that is by the (...) combination of one of the three forms of the cursus with one of the standard metrical forms derived from Cicero's system — cretic-spondee, dicretic, cretic-tribrach, or ditrochee. (shrink)

The United Nations (UN) Universal Declaration of Human Rights engenders important state commitments to respect, fulfill, and protect a broad range of socio-economic rights. In 2010, a milestone was reached when the UN General Assembly recognized the human right to safe and clean drinking water and sanitation. However, water plays an important role in realizing other human rights such as the right to food and livelihoods, and in realizing the Convention on the Elimination of All Forms of Discrimination against Women. (...) These broader water-related rights have been recognized but have not yet been operationalized. This paper unravels these broader water-related rights in a more holistic interpretation of existing international human rights law. By focusing on an emerging approach to water services provision—known as ‘domestic-plus’ services—the paper argues how this approach operationalizes a comprehensive range of socio-economic rights in rural and peri-urban areas. Domestic-plus services provide water for domestic and productive uses around homesteads, which challenges the widespread practice in the public sector of planning and designing water infrastructure for a single-use. Evidence is presented to show that people in rural communities are already using their water supplies planned for domestic uses to support a wide range of productive activities. Domestic-plus services recognize and plan for these multiple-uses, while respecting the priority for clean and safe drinking water. The paper concludes that domestic-plus services operationalize the obligation to progressively fulfill a comprehensive range of indivisible socio-economic rights in rural and peri-urban areas. (shrink)

Nanotechnology, as with many technologies before it, places a strain on existing legislation and poses a challenge to all administrative agencies tasked with regulating technology-based products. It is easy to see how statutory schemes become outdated, as our ability to understand and affect the world progresses. In this article, we address the regulatory problems that nanotechnology posses for the Food and Drug Administration’s (FDA) classification structure for ‘‘drugs’’ and ‘‘devices.’’ The last major modification to these terms was in 1976, with (...) the enactment of the Medical Device Amendments. There are serious practical differences for a classification as a drug or device in terms of time to market and research. Drugs are classified, primarily, as acting by ‘‘chemical action.’’ We lay out some legal, philosophic, and scientific tools that serve to provide a useful, as well as legally and scientifically faithful, distinction between drugs and devices for the purpose of regulatory classification. These issues we raise are worth the consideration of anyone who is interested in the regulation of nano-products or other novel technologies. (shrink)

We study the relationships between definitions of compactness in topological spaces and the roll the axiom of choice plays in these relationships.

In several recent studies we have developed precise statistical methodologies which have demonstrated that the cursus mixtus was the dominant rhythmical system for final clausulae in Latin prose from the third century a.d. to the fifth. The cursus mixtus consisted of four standard metrical forms derived from the richer variety of Cicero's Asiatic tradition – cretic-spondee, dicretic, cretic-tribrach and ditrochee –, which were structured according to three accentual patterns – planus, tardus and velox. The latter are differentiated by the number (...) of unstressed syllables intervening between and following two accented syllables. The planus has two unaccented syllables between two word accents and one after the last accent. The tardus has two between two accents and two after the last accent. The velox has four between two accents and one after the last accent. The four metrical forms are contained within the parameters of the accentual cadences. The planus contains either the cretic-spondee or the ditrochee ; the tardus either the dicretic or the cretic-tribrach ; the velox either the ditrochee or the cretic-spondee (nimium videbatur. Authors who used the cursus mixtus, however, preferred to effect an exact coincidence between the accent and ictus, and as a result evinced primarily the following standard rhythmical forms: planus/cretic-spondee; tardus/dicretic or cretic-tribrach; and velox/ditrochee. So far now we have examined only the rhythmical properties of final clausulae, but it is appropriate also to investigate for rhythm at internal positions within the sentence. (shrink)

This Is A New Release Of The Original 1920 Edition.

This article evaluates the oversight of drugs and medical devices by the U.S. Food and Drug Administration using an integration of public policy, law, and bioethics approaches and employing multiple assessment criteria, including economic, social, safety, and technological. Criteria assessment and expert elicitation are combined with existing literature, case law, and regulations in an integrative historical case studies approach. We then use our findings as a tool to explore possibilities for effective oversight and regulatory mechanisms for nanobiotechnology. Section I describes (...) oversight mechanisms for human drugs and medical devices and presents current nanotechnology products. Section II describes the results of expert elicitation research. Section III highlights key criteria and relates them to the literature and larger debate. We conclude with broad lessons for the oversight of nanobiotechnology informed by Sections I-III in order to provide useful analysis from multiple disciplines and perspectives to guide discussions regarding appropriate FDA oversight. (shrink)

This article evaluates the oversight of drugs and medical devices by the U.S. Food and Drug Administration using an integration of public policy, law, and bioethics approaches and employing multiple assessment criteria, including economic, social, safety, and technological. Throughout, assessments employing both the multiple criteria and a method of expert elicitation are combined with the existing literature, case law, and regulations providing an integrative historical case study approach. The goal is to provide useful information from multiple disciplines and perspectives to (...) guide discussions regarding appropriate oversight frameworks for nanobiotechnology applications under the FDA’s purview. (shrink)

Nanomedicine is yielding new and improved treatments and diagnostics for a range of diseases and disorders. Nanomedicine applications incorporate materials and components with nanoscale dimensions where novel physiochemical properties emerge as a result of size-dependent phenomena and high surface-to-mass ratio. Nanotherapeutics and in vivo nanodiagnostics are a subset of nanomedicine products that enter the human body. These include drugs, biological products, implantable medical devices, and combination products that are designed to function in the body in ways unachievable at larger scales. (...) Nanotherapeutics andin vivonanodiagnostics incorporate materials that are engineered at the nanoscale to express novel properties that are medicinally useful. These nanomedicine applications can also contain nanomaterials that are biologically active, producing interactions that depend on biological triggers. Examples include nanoscale formulations of insoluble drugs to improve bioavailability and pharmacokinetics, drugs encapsulated in hollow nanoparticles with the ability to target and cross cellular and tissue membranes and to release their payload at a specific time or location, imaging agents that demonstrate novel optical properties to aid in locating micrometastases, and antimicrobial and drug-eluting components or coatings of implantable medical devices such as stents. (shrink)

Delivering high quality genomics-informed care to patients requires accurate test results whose clinical implications are understood. While other actors, including state agencies, professional organizations, and clinicians, are involved, this article focuses on the extent to which the federal agencies that play the most prominent roles — the Centers for Medicare and Medicaid Services enforcing CLIA and the FDA — effectively ensure that these elements are met and concludes by suggesting possible ways to improve their oversight of genomic testing.

In these three lectures, Cavell situates Emerson at an intersection of three crossroads: a place where both philosophy and literature pass; where the two traditions of English and German philosophy shun one another; where the cultures of America and Europe unsettle one another. "Cavell’s ’readings’ of Wittgenstein and Heidegger and Emerson and other thinkers surely deepen our understanding of them, but they do much more: they offer a vision of what life can be and what culture can mean.... These profound (...) lectures are a wonderful place to make [Cavell’s] acquaintance."—Hilary Putnam. (shrink)

This book is Stanley Cavell’s definitive expression on Emerson. Over the past thirty years, Cavell has demonstrated that he is the most emphatic and provocative philosophical critic of Emerson that America has yet known. The sustained effort of that labor is drawn together here for the first time into a single volume, which also contains two previously unpublished essays and an introduction by Cavell that reflects on this book and the history of its emergence. -/- Students and scholars working (...) in philosophy, literature, American studies, history, film studies, and political theory can now more easily access Cavell’s luminous and enduring work on Emerson. Such engagement should be further complemented by extensive indices and annotations. If we are still in doubt whether America has expressed itself philosophically, there is perhaps no better space for inquiry than reading Cavell reading Emerson. (shrink)

Stanley Cavell has been a brilliant, idiosyncratic, and controversial presence in American philosophy, literary criticism, and cultural studies for years. Even as he continues to produce new writing of a high standard -- an example of which is included in this collection -- his work has elicited responses from a new generation of writers in Europe and America. This collection showcases this new work, while illustrating the variety of Cavell's interests: in the "ordinary language" philosophy of Wittgenstein and Austin, (...) in film criticism and theory, in literature, psychoanalysis, and the American transcendentalism of Ralph Waldo Emerson and Henry David Thoreau. The collection also reprints Richard Rorty's early review of Cavell's magnum opus, The Claim of Reason (1979), and it concludes with Cavell's substantial set of responses to the essays, a highlight of which is his engagement with Rorty. (shrink)

In replying to Jay Schleusener, I have also answered many of the objections put less abstractly, though often more sharply, by Stanley Fish. For instance, Fish's assertion that my category of unintended negative consequences "will be filled by whatever does not accord with what Rader has decreed to be the positive constructive intention" is essentially the same charge brought by Schleusener and requires no further substantive answer than I have already offered here and, for that matter, in my original (...) essay. I would point out, however, that in this remark as elsewhere Fish loads his statements with inaccurate pejoratives: I do not decree but postulate the positive constructive intention and test it for explanatory adequacy by deduction open at every point to the counterdemonstration of fallacy. I would point out also that, in making this charge, he operates under different explanatory standards from those he adopts elsewhere. The statement quoted imputes to my theory as a special defect the fact of its supposedly self-fulfilling and nonfalsifiable character, whereas later Fish clearly asserts that all interpretations including his own are necessarily self-confirming. Ralph W. Rader has written Tennyson's "Maud": The Biographical Genesis. Among his influential articles are "Literary Form in Factual Narrative: The Example of Boswell's Johnson" and "The Concept of Genre and Eighteenth-Century Studies." He is professor of English at the University of California at Berkeley. His contributions to Critical Inquiry include "Fact, Theory, and Literary Explanation" , "The Dramatic Monologue and Related Lyric Forms", and "The Literary Theoretical Contribution of Sheldon Sacks". (shrink)

The willows and the hazel copses greenShall now no more be seenFanning their joyous leaves to thy soft lays.[Milton, Lycidas, Ll. 42-44] It is my thesis that the reader is always making sense , and in the case of these lines the sense he makes will involve the assumption of a completed assertion after the word "seen," to wit, the death of Lycidas has so affected the willows and the hazel copses green that, in sympathy, they will wither and die (...) . In other words at the end of line 43 the reader will have hazarded an interpretation, or performed an act of perpetual closure, or made a decision as to what is being asserted. I do not mean that he has done four things, but that he has done one thing the description of which might take any one of four forms—making sense, interpreting, performing perpetual closure, deciding about what is intended. Whatever he has done he will undo it in the act of reading the next line; for here he discovers that his closure, or making of sense, was premature and that he must make a new one in which the relationship between man and nature is exactly the reverse of what was first assumed. The willows and the hazel copses green will in fact be seen, but they will not be seen by Lycidas. It is he who will be no more, while they go on as before, fanning their joyous leaves to someone else's soft lays . Nature is not sympathetic, but indifferent, and the notion of her sympathy is one of those "false surmises" that the poem is continually encouraging and then disallowing. Stanley E. Fish, professor of English at Johns Hopkins University, is the author of John Skelton's Poetry, Surprised by Sin: The Reader in Paradise Lost, and Self-Consuming Artifacts: The Experience of Seventeenth-Century Literature. His other contributions to Critical Inquiry include "Facts and Fictions: A Reply to Ralph Rader" , "Normal Circumstances, Literal Language, Direct Speech Acts, the Ordinary, the Everyday, the Obvious, What Goes without Saying, and Other Special Cases" , "A Reply to John Reichert; or, How to Stop Worrying and Learn to Love Interpretation" , and "One More Time" . See also: "Professor Fish on the Milton Variorum" by Douglas Bush in Vol. 3, No. 1; "Stanley Fish's 'Interpreting the Variorum': Advance or Retreat?" by Steven Mailloux in Vol. 3, No. 1; "Interpreting 'Interpreting the Variorum'" by Stanley E. Fish in Vol. 3, No. 1. (shrink)

Ralph Rader's model of literary activity is built up from a theory of intention. A literary work, he believes, embodies a "cognitive act,"1 an act variously characterized as a "positive constructive intention" , "an overall creative intention" . To read a literary work is to perform an answering "act of cognition" , which is in effect the comprehension of this comprehensive intention, the assigning to the work of a "single coherent meaning" . Both acts—the embodying and the assigning —are (...) one-time, single-shot performances. They are "ends" in two senses; the overall intention is the end to which everything in the work must be contributory, and its comprehension is something the reader does at the end . Rader offers this model as if it were descriptive, as if it made explicit rules of behavior we unerringly follow, rules which underlie our "tacit or intuitive capacity" of intention producing and intention retrieving; but the model is, in fact, prescriptive since it quite arbitrarily limits this same capacity: authors are limited to no more than one positive constructive intention per unit, while readers or interpreters are limited to its discovery; whatever cannot be related to that discovery or interferes with it will either be declared not to exist or, if its existence cannot be denied, it will be labeled a defect, an "unintended and unavoidable negative consequence of the artist's positive constructive intention" . · 1. My argument will engage two of Rader's articles. They are "Fact, Theory, and Literary Explanation," Critical Inquiry 1, no.2 : 245-72, and "The Concept of Genre and Eighteenth-Century Studies," in New Approaches to Eighteenth-Century Literature: Selected Papers from the English Institute , pp. 79-115. In what follows they will be referred to as Fact and Concept along with the appropriate page number. Stanley E. Fish, professor of English at John Hopkins University, responds in this essay to Ralph W. Rader's "Fact, Theory, and Literary Explanation" . Professor Fish is the author of John Skelton's Poetry, Surprised by Sin: The Reader in Paradise Lost, and Self-Consuming Artifacts: The Experience of Seventeenth-Century Literature. His other contributions to Critical Inquiry include "Interpreting the Variorum" , "CRITICAL RESPONSE: Interpreting 'Interpreting the Variorum'" , "Normal Circumstances, Literal Language, Direct Speech Acts, the Ordinary, the Everyday, the Obvious, What Goes without Saying, and Other Special Cases" , "CRITICAL RESPONSE: A Reply to John Reichert; or, How to Stop Worrying and Learn to Love Interpretation" , and "One More Time". (shrink)

We are free to get our theories where we will. As Einstein said, the emergence of a theory is like an egg laid by a chicken, "auf einmal ist es da.1" In practice theories are usually derived as improvements on earlier theories, as better tools are refinements of earlier, cruder ones; and they are directed explanatorily not at the facts of their own construction but at independently specifiable facts which, left unexplained by earlier theories, have therefore refuted them. A new (...) theory should cogently and directly explain all that its predecessors explain and in addition those particular facts which they conspicuously do not explain. The ideal is to have the simplest possible premises explaining most precisely the widest possible range of problematical facts. · 1. Ronald W. Clark, Einstein: The Life and Times , p.173 n. Ralph W. Rader has written Tennyson's "Maud": The Biographical Genesis. Among his influential articles are "Literary Form in Factual Narrative: The Example of Boswell's Johnson" and "The Concept of Genre and Eighteenth-Century Studies." He is professor of English at the University of California at Berkeley. His contributions to Critical Inquiry are "Explaining Our Literary Understanding: A Response to Jay Schleusener and Stanley Fish" , "The Dramatic Monologue and Related Lyric Forms", and "The Literary Theoretical Contribution of Sheldon Sacks". (shrink)

The most distinctive and highly valued poems of the modern era offer an image of a dramatized "I" acting in a concrete setting. The variety and importance of the poems which fall under this description are suggested simply by the mention of such names as "Elegy Written in a Country Courtyard," "Tintern Abbey," "Ode to a Nightingale," "Ulysses," "My Last Duchess," "Dover Beach," "The Windhover," "The Darkling Thrush," "Sailing to Byzantium," "Leda and the Swan," "The Love Song of J. Alfred (...) Prufrock," "Stopping by Woods on a Snowy Evening." The power and beauty of such poems seems intimately connected with the fact of their dramatic integrity and autonomy, and we have all been taught, in analyzing them, to refer to a "speaker" existing independent of the poet and to avoid the "intentional" and "biographical" fallacies which spuriously link the poem to the poet and the world outside the poem. Such an approach tends to undercut any notion that a poem has a single definite meaning, the meaning the poet gave it, and to support the idea that the meaning of a poem is indeterminate and/or multiple. All this is quite in accord with the orthodox critical doctrine that poetic language is differentiated from scientific language and preserved from competition with it by the fact that it is nonreferential, making no claim upon the real world; and complex, indefinite, and alogical, where scientific language is simple, definite, and logical. Ralph W. Rader is chairman of the department of English at the University of California at Berkeley. His previous contributions to Critical Inquiry are "Fact, Theory, and Literary Explanation" , "Explaining Our Literary Understanding: A Response to Jay Schleusener and Stanley Fish" , and "The Literary Theoretical Contribution of Sheldon Sacks" . Professor Rader's influential studies include Tennyson's "Maud": The Biography Genesis, "Literary Form in Factual Narrative: The Example of Boswell's Johnson," and "The Concept of Genre and Eighteenth-century Studies.". (shrink)

Behind all of Sheldon Sacks' writing and teaching lay an intense belief in the objectivity of literary experience and our capacity to achieve a shared conceptual understanding of the forms which underlie it. Literary criticism for him was not the critic's unique and unrepeatable performance but a serious inquiry—a critical inquiry—seeking explicit and precise explanatory concepts which others could grasp, test, and build upon. His effort was to show that we could in significant measure understand and explain literature and its (...) value as standing independent of our understanding and explanation, and it was this double emphasis on the real being of literature and the possibility of valid conceptualization of it which gave his thought its appeal for those whom it influences. His creative constitution—and the length and circumstances of his life—were such as to allow only the one sustained effort of Fiction and the Shape of Belief and a series of articles in which he modified and expanded the application of the ideas developed therein. Yet in this relatively small body of work he revised and extended the ideas of the Chicago School within which he worked so as to achieve what seem to me genuine advances in the explicit conception of novelistic forms—what might be called portable ideas, sharp and definite enough to be adopted and used and in their turn revised and redefined by others; this sets them apart from much critical work and marks their value and his intention. Ralph W. Rader, chairman of the department of English at the University of California at Berkeley, is the author of Tennyson's "Maud": The Biographical Genesis. His previous contributions to Critical Inquiry are "Fact, Theory, and Literary Explanation" , "Explaining Our Literary Understanding: A Response to Jay Schleusener and Stanley Fish" , and "The Dramatic Monologue and Related Lyric Forms". (shrink)

A sentence is never not in a context. We are never not in a situation. A statute is never not read in the light on some purpose. A set of interpretative assumptions is always in force. A sentence that seems to need no interpretation is already the product of one...No sentence is ever apprehended independently of some or other illocutionary force. Illocutionary force is the key term in speech-act theory. It refers to the way an utterance is taken—as an order, (...) a warning, a promise, a proposal, a request, etc.—and the theory's strongest assertion is that no utterance is ever taken purely, that is, without already having been understood as the performance of some illocutionary act. Consider, as an example, the sentence "I will go." Depending on the context in which it is uttered, "I will go" can be understood as a promise, a threat, a warning, a report, a prediction, etc., but it will always be understood as one of these, and it will never be an unsituated kernel of pure semantic value. In other words, "I will go" does not have a basic or primary meaning which is then put to various illocutionary uses; rather, "I will go" is known only in its illocutionary lives, and in each of them its meaning will be different. Moreover, if the meaning of a sentence is a function of its illocutionary force , and if illocutionary force varies with the circumstances, then illocutionary force is not a property of sentences, but of situations. That is, while a sentence will always have an illocutionary force , the illocutionary force it has will not always be the same. Stanley E. Fish is the author of, among many other works, Is There a Text in This Class? Interpretative Authority in the Classroom and in Literary Criticism, and The Living Temple: George Herbert and Catechizing. His contributions to Critical Inquiry include "Facts and Fictions: A Reply to Ralph Rader" , "Interpreting the Variorum" , "Interpreting 'Interpreting the Variorum'" , "A Reply to John Reichert; or, How to Stop Worrying and Learn to Love Interpretation" , and "One More Time". (shrink)

In these three lectures, Cavell situates Emerson at an intersection of three crossroads: a place where both philosophy and literature pass; where the two ...

I could go on in this way, replying to Reichert's reply, point by point, but the pattern of my replies is already set: he charges that my position entails certain undesirable consequences and flies in the face of some of our most basic intuitions; I labor to show that none of those consequences follow and that our basic intuitions are confirmed rather than denied by what I have to say. This of course is exactly what I was doing in the (...) article to which he takes exception and will soon do at length in a book to be published within the year. I am not, however, optimistic that a reading of that book will make Reichert a convert because the fears that impel his argument are so basic to his beliefs. I take the key sentence in his article to be this one: "Since I would like to think that I read the same King Lear that Dr. Johnson read, and am therefore free to disagree with his interpretation of it, I would like to find a way out of Fish's formulation of the reader's situation" . Reichert's commitment to what he would like to be able to do and his conviction that if what I say is true he will be unable to do it make it impossible for him to regard my position as anything but perverse and dangerous. Even if I could demonstrate in his own terms that his fears are unfounded—that he is still free to disagree with Dr. Johnson or anyone else—any argument I might make would be received within the belief that it had to be wrong, and within that belief he could only hear it as wrong. To this Reichert would probably reply that arguments are either good or bad, irrespective of beliefs, and that mine are bad; but it is my contention that arguments are forceful only within a set of beliefs and that unless someone is willing to entertain the possibility that his beliefs are wrong he will be unable even to hear an argument that constitutes a challenge to them. That is why the fact that Reichert is likely to remain unconvinced by my argument is its strongest confirmation. Stanley Fish is the author of, among other works, Is There a Text in This Class? Interpretative Authority in the Classroom and in Literary Criticism. His contributions to Critical Inquiry include "Facts and Fictions: A Reply to Ralph Rader" , "Interpreting the Variorum" , "Interpreting 'Interpreting the Variorum'" , "Normal Circumstances, Literal Language, Direct Speech Acts, the Ordinary, the Everyday, the Obvious, What Goes without Saying, and Other Special Cases" , and "One More Time". (shrink)